Since being released on the world in 2012, the biotechnological tool CRISPR has been making headlines. Biologists used to rely on the relatively blunt tools of genetic modification, but this new tool is so precise and versatile that they now speak of gene editing instead. For people in a hurry, Nessa Carey here provides a primer on the powers and pitfalls of gene editing. Hacking the Code of Life is accessible to readers without much background in genetics, focusing more on the applications and the questions it raises than the nitty-gritty details of the tool itself.
The problem with many history books is that they are written long after the facts, sometimes when the original protagonists are no longer alive. Historians or journalists often have no choice but to puzzle together the pieces of their story from eyewitness testimony or archival sources. Kin: How We Came to Know Our Microbe Relatives is a welcome exception to this rule. Written by emeritus microbiology professor John L. Ingraham, currently 94 years young, this book gives an intellectual history of the discipline of microbiology based on over seven decades of first-hand involvement and observation.
In my recent review of She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity, I mentioned how the concept of heredity has become ever fuzzier the more we have learnt about how traits can be passed to the next generation. We have come from a very gene-centric period in biology, but biologists Russell Bonduriansky and Troy Day are ready to shake up the field. Neither a Lamarckian redux nor an attempt to downplay the importance of genes, this book successfully argues that the time has come to take into account non-genetic forms of heredity. Along the way, they provide a very interesting history lesson on how we got here in the first place.
As one of several intellectuals who wrote about evolution before Darwin, time has not been kind to the French naturalist Jean-Baptiste Lamarck (1744-1829). Reviled during his lifetime by the influential Cuvier, after his death he became best remembered, and ultimately ridiculed, for the idea that characters acquired during an organism’s lifetime are passed on to its offspring. With the rise of the modern field of epigenetics, some of his ideas are making a comeback, albeit modified and adapted for the 21st Century. Palaeontologist and astrobiologist Peter Ward would even like to go so far as to restore some honour to his name and consider epigenetics a neo-Lamarckian process.
When I opened this book and read its sales pitch (I paraphrase: “What if I told you of a new fortune-telling device that can predict psychological traits – it’s called the DNA revolution!”) I raised my inquisitive but sceptical eyebrow somewhat. Did I just pick up another piece of pop-psychology pulp? Oh boy, was I wrong! Behavioural geneticist Robert Plomin has written an incredibly interesting book with Blueprint, explaining how rapid advances in DNA sequencing technology are opening vast new vistas on the genetics underlying psychology. And is it ever so different, and more complex, than what hyped-up newspaper headlines have tried to sell us so far.
Who could refuse such an invitation to dinner? In fourteen short chapters, Dinner with Darwin provides a smörgåsbord of topics on the role of food in human evolution and vice versa, many of which have been covered here in recent reviews. This is Jonathan Silvertown’s fourth book with the University of Chicago Press, and based on this, I would love to read his other books as well. Care to join me at the table?
After I recently finished Carl Zimmer’s new book She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity, I noticed there was one mechanism of heredity he mentioned only ever so briefly: horizontal gene transfer. Since it does not play a large role in humans, it is understandable he left it aside. And doing it justice would have required almost another book. Luckily, science writer David Quammen is here to give us that book.
If Charles Darwin were to walk into my office today and ask me: “So, what did I miss?” I think I would sit the good man down with a copy of She Has Her Mother’s Laugh, telling him: “Here, this should get you up to speed”. Darwin struggled to explain how traits were being inherited from generation to generation. As New York Times columnist Carl Zimmer shows in this wide-ranging book, the story of heredity has turned out to be both diverse and wonderful, but has also been misappropriated to prop up some horrible ideologies.
As a biologist, the opposition to genetically modified organisms (GMOs) both baffles and vexes me. Spurious claims are being bandied about by people and organisations who seemingly haven’t a clue about genetics, and there has been a long-running campaign of fearmongering by large conservation bodies, notably Greenpeace. Like the “debate” around climate change or creationism, the dialogue has become toxic and polarised, and anyone who does not oppose is likely to be called a “Monsanto shill”. As this is first and foremost a book review though, I will try to keep my personal views on this issue aside for another time. This book, then, has a very interesting premise. A book arguing why we got it wrong by on GMOs, written by a former anti-GMO activist.
After recently reading Doudna & Sternberg’s book A Crack in Creation, this book was the next one I wanted to read to learn more about CRISPR-Cas9, the new technique to edit genetic material that has been taking the world by storm. As it turns out, it was the right order to read the books in. If you have not heard of CRISPR before, I recommend you have a look at my review of Doudna’s book first.