CRISPR-Cas9

Book review – Kin: How We Came to Know Our Microbe Relatives

The problem with many history books is that they are written long after the facts, sometimes when the original protagonists are no longer alive. Historians or journalists often have no choice but to puzzle together the pieces of their story from eyewitness testimony or archival sources. Kin: How We Came to Know Our Microbe Relatives is a welcome exception to this rule. Written by emeritus microbiology professor John L. Ingraham, currently 94 years young, this book gives an intellectual history of the discipline of microbiology based on over seven decades of first-hand involvement and observation.

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Book review – Extended Heredity: A New Understanding of Inheritance and Evolution

In my recent review of She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity, I mentioned how the concept of heredity has become ever fuzzier the more we have learnt about how traits can be passed to the next generation. We have come from a very gene-centric period in biology, but biologists Russell Bonduriansky and Troy Day are ready to shake up the field. Neither a Lamarckian redux nor an attempt to downplay the importance of genes, this book successfully argues that the time has come to take into account non-genetic forms of heredity. Along the way, they provide a very interesting history lesson on how we got here in the first place.

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Book review – Lamarck’s Revenge: How Epigenetics Is Revolutionizing Our Understanding of Evolution’s Past and Present

As one of several intellectuals who wrote about evolution before Darwin, time has not been kind to the French naturalist Jean-Baptiste Lamarck (1744-1829). Reviled during his lifetime by the influential Cuvier, after his death he became best remembered, and ultimately ridiculed, for the idea that characters acquired during an organism’s lifetime are passed on to its offspring. With the rise of the modern field of epigenetics, some of his ideas are making a comeback, albeit modified and adapted for the 21st Century. Palaeontologist and astrobiologist Peter Ward would even like to go so far as to restore some honour to his name and consider epigenetics a neo-Lamarckian process.

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Book review – Blueprint: How DNA Makes Us Who We Are

When I opened this book and read its sales pitch (I paraphrase: “What if I told you of a new fortune-telling device that can predict psychological traits – it’s called the DNA revolution!”) I raised my inquisitive but sceptical eyebrow somewhat. Did I just pick up another piece of pop-psychology pulp? Oh boy, was I wrong! Behavioural geneticist Robert Plomin has written an incredibly interesting book with Blueprint, explaining how rapid advances in DNA sequencing technology are opening vast new vistas on the genetics underlying psychology. And is it ever so different, and more complex, than what hyped-up newspaper headlines have tried to sell us so far.

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Book review – Tomorrow’s Table: Organic Farming, Genetics, and the Future of Food (Second Edition)

Aaah, GMOs. Was there ever a topic comparable to genetically modified organisms that riled people on either side of the debate this much? Written by an organic farmer and plant geneticist, Tomorrow’s Table is a marvellous work that walks the middle road, asking: Why should we not combine the best that organic farming and genetic engineering have to offer? Along the way, it exposes the often illogical, contradictory and, frankly, infuriating attitudes and opinions of the anti-GMO movement, politely smothering them with facts, while also teaching the technology cheerleaders a lesson or two. I love this book.

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Book review – The Tangled Tree: A Radical New History of Life

After I recently finished Carl Zimmer’s new book She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity, I noticed there was one mechanism of heredity he mentioned only ever so briefly: horizontal gene transfer. Since it does not play a large role in humans, it is understandable he left it aside. And doing it justice would have required almost another book. Luckily, science writer David Quammen is here to give us that book.

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Book review – She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity

If Charles Darwin were to walk into my office today and ask me: “So, what did I miss?” I think I would sit the good man down with a copy of She Has Her Mother’s Laugh, telling him: “Here, this should get you up to speed”. Darwin struggled to explain how traits were being inherited from generation to generation. As New York Times columnist Carl Zimmer shows in this wide-ranging book, the story of heredity has turned out to be both diverse and wonderful, but has also been misappropriated to prop up some horrible ideologies.

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Book review – Planet of Microbes: The Perils and Potential of Earth’s Essential Life Forms

What unites deep subterranean caves, hydrothermal vents in the deep sea, our guts, cloud formation, geochemical processes, and astrobiology (the search for life beyond our planet) to name but a few things? Microbes. The tiny, single-celled organisms that we cannot see with the naked eye are everywhere. With Planet of Microbes, Ted Anton makes the point that this world is really theirs, and takes the reader on a tour of the rapid increase in our understanding of their importance, focusing on three major subjects.

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Book review – Modern Prometheus: Editing the Human Genome with CRISPR-Cas9

After recently reading Doudna & Sternberg’s book A Crack in Creation, this book was the next one I wanted to read to learn more about CRISPR-Cas9, the new technique to edit genetic material that has been taking the world by storm. As it turns out, it was the right order to read the books in. If you have not heard of CRISPR before, I recommend you have a look at my review of Doudna’s book first.

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Book review – A Crack in Creation: The New Power to Control Evolution

If you follow science news, chances are you will have heard of CRISPR as a promising new way to modify DNA. It has been hailed as a breakthrough discovery. I knew little about it, and seeing that this book is written by one of the co-inventors, it seemed like a good place to start reading about it.

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